Aprovasc 300/5 28's

APROVASC 300/5 28`S genuine hypertension product, available in store and online. Irbesartan/amlodipine (Aprovasc) is an angiotensin receptor blocker/calcium channel blocker fixed dose single pill combination, whose constituent drugs exert additive effects when coadministered. It is indicated in patients whose blood pressure is not adequately controlled on irbesartan or amlodipine monotherapy. Irbesartan and Amlodipine: The pharmacodynamic properties of each drug, Irbesartan and Amlodipine, provide an addition of antihypertensive effects when administered in combination against the effect observed with both components separately. Both the AT1 receptor blocker and the calcium channel antagonist lower blood pressure by reducing peripheral resistance, but blocking calcium flow and reducing vasoconstriction by angiotensin II are complementary mechanisms. Irbesartan: Mechanism of action: Irbesartan is a specific antagonist of angiotensin II receptors (AT1 subtype). Angiotensin II is an important component of the renin angiotensin system, it participates in the pathophysiology of hypertension and in sodium homeostasis. Irbesartan does not require metabolic activation for its action. Irbesartan blocks the potent vasoconstriction and aldosterone secretion effects produced by angiotensin II, by selective antagonism of angiotensin II receptors (AT1 subtype) located in vascular smooth muscle cells and in the adrenal cortex. Irbesartan has no agonist activity at the AT1 receptor and has a much higher affinity (more than 8,500 times) for the AT1 receptor than for the